학술논문
Prognostic significance of the albumin-to-globulin ratio for upper tract urothelial carcinoma
Document Type
Academic Journal
Author
Source
BMC Urology. August 28, 2020, Vol. 20 Issue 1
Subject
Language
English
ISSN
1471-2490
Abstract
Author(s): Shota Omura[sup.1], Satoru Taguchi[sup.1], Shogo Miyagawa[sup.1], Ryuki Matsumoto[sup.1], Mio Samejima[sup.1], Naoki Ninomiya[sup.1], Kazuki Masuda[sup.1], Yu Nakamura[sup.1], Tsuyoshi Yamaguchi[sup.1], Manami Kinjo[sup.1], Mitsuhiro Tambo[sup.1], Takatsugu Okegawa[sup.1], Eiji Higashihara[sup.2] and Hiroshi Fukuhara[sup.1] [...]
Background Although the albumin-to-globulin ratio (AGR) is a promising biomarker for various malignancies, few studies have investigated its prognostic significance for upper tract urothelial carcinoma (UTUC). Methods This retrospective study conformed to the REporting recommendations for tumour MARKer prognostic studies (REMARK) guideline. We reviewed 179 patients with UTUC who underwent radical nephroureterectomy at our institution between 2008 and 2018. Associations of preoperative clinicopathological factors, including the AGR, with cancer-specific survival (CSS) and overall survival (OS) were assessed. The Cox proportional hazards model was used for univariate and multivariable analyses. AGR was dichotomized as < 1.25 and [greater than or equai to] 1.25, according to the most discriminatory cutoff determined from the receiver operating characteristic curve analysis. Results During a median follow-up of 34 months after surgery, 37 patients died from UTUC and 13 died of other causes. The preoperative AGR significantly correlated with pathological T stage, pathological N stage, and adjuvant chemotherapy. Multivariate analyses demonstrated that a decreased (< 1.25) preoperative AGR was an independent poor prognostic factor for both CSS (hazard ratio [HR] = 2.81, P < 0.01) and OS (HR = 2.09, P < 0.05). Conclusions Preoperative AGR < 1.25 might serve as a useful prognostic marker for patients with UTUC undergoing radical nephroureterectomy. Keywords: AGR, Albumin-to-globulin ratio, Biomarker, Radical nephroureterectomy, REMARK, Upper tract urothelial carcinoma
Background Although the albumin-to-globulin ratio (AGR) is a promising biomarker for various malignancies, few studies have investigated its prognostic significance for upper tract urothelial carcinoma (UTUC). Methods This retrospective study conformed to the REporting recommendations for tumour MARKer prognostic studies (REMARK) guideline. We reviewed 179 patients with UTUC who underwent radical nephroureterectomy at our institution between 2008 and 2018. Associations of preoperative clinicopathological factors, including the AGR, with cancer-specific survival (CSS) and overall survival (OS) were assessed. The Cox proportional hazards model was used for univariate and multivariable analyses. AGR was dichotomized as < 1.25 and [greater than or equai to] 1.25, according to the most discriminatory cutoff determined from the receiver operating characteristic curve analysis. Results During a median follow-up of 34 months after surgery, 37 patients died from UTUC and 13 died of other causes. The preoperative AGR significantly correlated with pathological T stage, pathological N stage, and adjuvant chemotherapy. Multivariate analyses demonstrated that a decreased (< 1.25) preoperative AGR was an independent poor prognostic factor for both CSS (hazard ratio [HR] = 2.81, P < 0.01) and OS (HR = 2.09, P < 0.05). Conclusions Preoperative AGR < 1.25 might serve as a useful prognostic marker for patients with UTUC undergoing radical nephroureterectomy. Keywords: AGR, Albumin-to-globulin ratio, Biomarker, Radical nephroureterectomy, REMARK, Upper tract urothelial carcinoma