학술논문

Hypergravity load-induced hyperglycemia occurs due to hypothermia and increased plasma corticosterone level in mice
Document Type
Academic Journal
Source
The Journal of Physiological Sciences. August 1, 2022, Vol. 72 Issue 1
Subject
Penicillin G
Corticosterone
Blood sugar
Hyperglycemia
Glucagon
Psychology and mental health
Language
English
ISSN
1880-6546
Abstract
Hypothermia has been observed during hypergravity load in mice and rats. This response is beneficial for maintaining blood glucose level, although food intake decreases. However, saving glucose is not enough to maintain blood glucose level during hypergravity load. In this study, we examined the contribution of humoral factors related to glycolysis in maintaining blood glucose level in a 2 G environment. Increased plasma corticosterone levels were observed in mice with intact peripheral vestibular organs, but not in mice with vestibular lesions. Plasma glucagon levels did not change, and decrease in plasma adrenaline levels was observed in mice with intact peripheral vestibular organs. Accordingly, it is possible that increase in plasma corticosterone level and hypothermia contribute to prevent hypoglycemia in a 2 G environment. Keywords: Gravity, Vestibular system, Adrenaline, Noradrenaline
Author(s): Chikara Abe[sup.1], Chikako Katayama[sup.1], Kazuhiro Horii[sup.1], Bakushi Ogawa[sup.1], Kento Ohbayashi[sup.2], Yusaku Iwasaki[sup.2], Fumiaki Nin[sup.1] and Hironobu Morita[sup.1] Introduction Gravity is a stressor that affects physiological homeostasis. All living organisms [...]