부산대학교 도서관

Delineation of the intricacies of protein function from macromolecular structure constitutes a continual obstacle in the study of cell and pathogen biology. Structure-based phylogenetic analysis has emerged as a powerful tool for addressing this challenge, allowing the detection and quantification of conserved architectural properties between proteins, including those with low or no detectable sequence homology. With a focus on viral protein structure, we highlight how a number of investigations have utilized this powerful method to infer common functionality and ancestry. Key words: virus; protein; structure; function; evolution.
1. Introduction Global genome sequencing initiatives have delivered abundant insights into the expansive viral biosphere (Li et al. 2015; Simmonds et al. 2017; Shi et al. 2018). Due to the [...]