부산대학교 도서관

Purpose: To evaluate the effectiveness and safety of a modified approach using the Ex-PRESS[R] implant combined with a scleral pocket in the management of secondary open-angle glaucoma in hereditary transthyretin amyloidosis (hATTR) at our department. Methods: This was a retrospective analysis. The primary endpoints included Intraocular pressure (IOP) evaluation (baseline, 1st day, 1st week, 1, 3, 6, 12 months and at last follow-up) and number of hypotensive drugs (baseline, 6th, 12th months and at last follow-up). As secondary endpoints surgical complications, the need for additional glaucoma surgery and LogMAR BCVA were evaluated. Qualified and complete success were defined as [greater than or equal to] 30% IOP decrease from baseline, with or without additional medications, respectively. The minimum follow-up was 12 months. Results: A total of 32 eyes were included with a mean follow-up of 2.4 [+ or -] 2.9 years. IOP decreased significantly from baseline (27.4 [+ or -] 4.4 mmHg) to 1st day (5.00 [+ or -] 2.9 mmHg), 1st week (6.9 [+ or -] 4.1 mmHg), 1st month (11.7 [+ or -] 7.8 mmHg), 3rd month (11.6 [+ or -] 6.1 mmHg), 6th month (13.1 [+ or -] 6.8 mmHg), 12th month (12.0[+ or -]3.5 mmHg) and last visit (11.8 [+ or -] 2.4 mmHg), p Conclusion: The modified ExPRESS[R] technique appears to be effective, especially when low levels of IOP are required. Additionally, fewer anti-glaucoma drugs were necessary. In the other hand, hypotony was a common side effect with this procedure, although all patients were properly handled, preserving the surgical outcomes. Keywords: amyloidosis, FAP glaucoma, hereditary transthyretin amyloidosis, hATTR
Introduction Familial amyloidotic polyneuropathy is caused by mutations in the gene encoding transthyretin, a protein mostly produced by the liver. This is an autosomal dominant disorder with adult-onset and variable [...]