부산대학교 도서관

Byline: T. V. Timoshenko (1), O. V. Perepelkina (1), N. V. Markina (1), A. V. Revischin (2,3), G. V. Pavlova (2,3), I. I. Poletaeva (1), G. T. Sukhih (3) Keywords: audiogenic epilepsy; semax, L-NAME; neonatal exposure; neurogenesis Abstract: Pups of Wistar and KM rats (with predisposition to audiogenic epilepsy) were daily injected with neuropeptide semax (50 mg/kg) or NO-synthase inhibitor L-NAME (50 mg/kg) on days 7-11 of life. Alterations of audiogenic seizures pattern were revealed in rats of both strains at the age of 1 month, while changes in seizure severity were genotype-dependent. Both agents enhance neurogenesis in the dentate gyrus of the hippocampus and the delayed effect in the form of altered seizure pattern seems to be determined by this factor. Genotype-dependent alterations of seizure severity after administration of semax and L-NAME were differently directed. These effects are suggested to be underlined by physiological and biochemical mechanisms not related to the intensity of postnatal neurogenesis. Author Affiliation: (1) Biological Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia (2) Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russia (3) V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Federal Agency of High-Technology Medical Service, Moscow, Russia Article History: Registration Date: 11/08/2009 Received Date: 13/10/2008 Online Date: 20/08/2009 Article note: Translated from Byulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 147, No. 4, pp. 441-444, April, 2009