부산대학교 도서관

Supplemental melatonin has been used to treat sleep onset insomnia in children with autism spectrum disorders (ASD), although the mechanism of action is uncertain. We assessed endogenous and supplemental melatonin profiles in relation to sleep in nine children with ASD. In endogenous samples, maximal melatonin concentration (Cmax) and time to peak concentration (Tmax) were comparable to those previously published in the literature for typically developing children, and dim light melatonin onsets were captured in the majority of children. In treatment samples (supplemental melatonin), melatonin parameters were also comparable to those previously published for typically developing children. Our findings support that children with ASD and insomnia responsive to low dose melatonin treatment have relatively normal profiles of endogenous and supplemental melatonin. Keywords Insomnia * N-acetylserotonin * Dim light melatonin onset
Introduction Autism spectrum disorders (ASD) are one of the most common neurodevelopmental disorders with a prevalence rate currently estimated in 1:88 children (Centers for Disease Control and Prevention 2012). Sleep [...]