부산대학교 도서관

Background: Cerebral small-vessel diseases (cSVDs) encompass a number of causes involving, but not limited to, alterations in the intracranial microvasculature, leading to the accumulation of brain tissue damage and the development of various degrees of cognitive impairment, behavioral alterations, gait instability, and localization signs, often associated with the occurrence of ischemic or hemorrhagic strokes. Summary: In 2021, although key questions remain unanswered, there is general agreement on the construct, its main pathophysiological bases, and the terms used to describe its main clinical and radiological features. However, this has not always been the case, and the 30th anniversary of Cerebrovascular Diseases is an opportunity to look back from 1991 to the present to understand how a number of features, sometimes considered independent, have been progressively brought together by successive scientific breakthroughs, gradually leading to the definition of the now widely accepted concept of cSVDs. Key Messages: In the course of this journey, we will detail with particular attention the role of what we consider 2 crucial events: the advent of cerebral MRI and the building of large cohorts with monogenic forms of small-vessel disease of the brain. Keywords: Cerebral small-vessel disease, Lacunes, Lacunar stroke, Lacunar syndrome, White matter hyperintensities, Brain MRI, Diffusion MRI
Author(s): Lina Grosset (corresponding author) [a,b]; Eric Jouvent [a,b,c] Introduction The concept of cerebral small-vessel disease (cSVD) is now widely recognized. The publication in 2013 of the STRIVE criteria [1], [...]