부산대학교 도서관

One of the most widely used and potent immunological adjuvants is a mixture of soluble triterpene glycosides purified from the soap bark tree (Quillaja saponaria). Despite challenges in production, quality control, stability and toxicity, the QS-21 fraction from this extract has exhibited exceptional adjuvant properties for a range of antigens. It possesses an ability to augment clinically significant antibody and T-cell responses to vaccine antigens against a variety of infectious diseases, degenerative disorders and cancers. The recent synthesis of active molecules of QS-21 has provided a robust method to produce this leading vaccine adjuvant in high purity as well as to produce novel synthetic QS-21 congeners designed to induce increased immune responsiveness and decreased toxicity.
Author(s): Govind Ragupathi [sup.[[dagger]]] [sup.3] , Jeffrey R Gardner [sup.2] , Philip O Livingston [sup.1] , David Y Gin [sup.2] Keywords : adjuvants; saponins; synthetic adjuvants; vaccines Molecular identification of [...]