부산대학교 도서관

Altered expression of microRNAs contributes to the heterogeneous biological behavior of human malignancies and it may correlate with the clinical pathological features of patients. The let-7 microRNA family is frequently downregulated in human cancers and its aberrant expression may be a useful marker for prediction of the clinical response to therapy in patients. In the present study, we analyzed the expression of three members of the let-7 family (let-7a-3p, let-7d-3p and let-7f), which remains largely uncharacterized in ovarian cancer tissues. We also investigated the function of let-7d-3p in the apoptosis and sensitization to chemotherapy in ovarian cancer cells. Our data from stem-loop quantitative RT-PCR showed that expression of let-7a-3p and let-7d-3p, but not let-7f, was significantly (P Key words: ovarian cancer, let-7, apoptosis, chemotherapy response, neoadjuvant therapy
Introduction MicroRNAs (miRNAs) are evolutionarily conserved small non-coding RNAs of 25 nucleotides in length that function as negative regulators of gene expression by either inhibiting translation or inducing degradation of [...]