학술논문
Bayesian estimation in NONMEM
Document Type
Report
Author
Source
CPT: Pharmacometrics & Systems Pharmacology. February 2024, Vol. 13 Issue 2, p192, 16 p.
Subject
Language
English
Abstract
INTRODUCTION Bayesian modeling frameworks in the context of drug development are appealing for several reasons. Namely, the natural ability to leverage prior information, the accommodation of complex model structures with [...]
: Bayesian estimation is a powerful but underutilized tool for answering drug development questions. In this tutorial, the principles of Bayesian model development, assessment, and prior selection will be outlined. An example pharmacokinetic (PK) model will be used to demonstrate the implementation of Bayesian modeling using the nonlinear mixed‐effects modeling software NONMEM.
: Bayesian estimation is a powerful but underutilized tool for answering drug development questions. In this tutorial, the principles of Bayesian model development, assessment, and prior selection will be outlined. An example pharmacokinetic (PK) model will be used to demonstrate the implementation of Bayesian modeling using the nonlinear mixed‐effects modeling software NONMEM.