학술논문
.sup.1H NMR and crystallographic evidence for tolerance of bulky electron withdrawing methanesulfonyl group on robustness of the U-motif in pyrazolo[3,4-d]pyrimidine core based 'Leonard linker' compounds and formation of plus (+) motif
Document Type
Author abstract
Source
Journal of Molecular Structure. Feb 17, 2007, Vol. 827 Issue 1-3, p88, 7 p.
Subject
Language
English
ISSN
0022-2860
Abstract
To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.molstruc.2006.05.022 Byline: Kamlakar Avasthi (a), Sheikh M. Farooq (a), Sangeeta Aswal (a), Resmi Raghunandan (b), Prakas R. Maulik (b) Keywords: X-ray crystallography; Arene interactions; U-motif; Chain motif and plus motif Abstract: X-ray crystallographic analysis of two new 'Leonard/trimethylene linker' compounds; 1,3-bis(4-methoxy-6-methylsulfonyl-lH-pyrazolo[3,4-d]pyrimidin-1-yl)propane (4a) and 1,3-bis(4-ethoxy-6-methylsulfonyl-lH-pyrazolo[3,4-d]pyrimidin-1-yl)propane (4b) not only confirm robustness of the unusual U-motif conformation seen in earlier related compounds (1 and 2) but in addition reveal novel chain motif formed due to intermolecular CHa[macron]O and CHa[macron]N interactions resulting in novel plus (+) motif. Author Affiliation: (a) Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow 226001, India (b) Molecular and Structural Biology Division, Central Drug Research Institute, Lucknow 226001, India Article History: Received 12 April 2006; Revised 9 May 2006; Accepted 9 May 2006 Article Note: (footnote) [star] CDRI Communication No. 6918.