학술논문
Ultrashort pulse electroporation: applications of high pulsed electric fields to induced caspase activation of human lymphocytes
Document Type
Conference
Author
Source
Conference Record of the Twenty-Fifth International Power Modulator Symposium, 2002 and 2002 High-Voltage Workshop. Power modulator symposium and high-voltage workshop Power Modulator Symposium, 2002 and 2002 High-Voltage Workshop. Conference Record of the Twenty-Fifth International. :667-670 2002
Subject
Language
ISSN
1076-8467
Abstract
Presents evidence for apoptosis, or programmed cell death, and up-regulation of a subset of important genes induced by intense electric fields of short duration (10's nsec). The fields are observed to perturb mitochondrial membranes and the compartmentalized intracellular environment of Jurkat T lymphocytes, and within hours caspase activation occurs. Intense, but low energy, fields can penetrate a biological cell and invoke mechanisms associated with apoptosis.