학술논문
Fatty acid metabolic reprogramming via mTOR-mediated inductions of PPARγ directs early activation of T cells
Document Type
article
Author
Source
Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
Subject
Language
English
ISSN
2041-1723
Abstract
PPARγ promotes free fatty acid uptake and also has a role in T cell regulation. Here the authors show that mTORC1-PPARγ signalling is needed for fatty acid uptake by activated CD4+T cells and for clonal expansion of these cells.