학술논문
Association of Heart Rate Variability With Silent Brain Infarcts in Patients With Atrial Fibrillation
Document Type
article
Author
Peter Hämmerle; Christian Eick; Sven Poli; Steffen Blum; Vincent Schlageter; Axel Bauer; Konstantinos D. Rizas; Ceylan Eken; Michael Coslovsky; Stefanie Aeschbacher; Philipp Krisai; Pascal Meyre; Jens Wuerfel; Tim Sinnecker; Jean-Marc Vesin; Jürg H. Beer; Giorgio Moschovitis; Leo H. Bonati; Christian Sticherling; David Conen; Stefan Osswald; Michael Kühne; Christine S. Zuern
Source
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
Subject
Language
English
ISSN
2297-055X
Abstract
Purpose: Silent brain infarcts (SBI) are frequently detected in patients with atrial fibrillation (AF), but it is unknown whether SBI are linked to autonomic dysfunction. We aimed to explore the association of autonomic dysfunction with SBI in AF patients.Methods: 1,358 AF patients without prior stroke or TIA underwent brain MRI and 5-min resting ECG. We divided our cohort into AF patients who presented in sinus rhythm (SR-group, n = 816) or AF (AF-group, n = 542). HRV triangular index (HRVI), standard deviation of normal-to-normal intervals, mean heart rate, root mean square root of successive differences of normal-to-normal intervals, 5-min total power and power in the low frequency, high frequency and very low frequency range were calculated. Primary outcome was presence of SBI in the SR group, defined as large non-cortical or cortical infarcts. Secondary outcomes were SBI volumes and topography.Results: Mean age was 72 ± 9 years, 27% were female. SBI were detected in 10.5% of the SR group and in 19.9% of the AF group (p < 0.001). HRVI