학술논문
Exploratory study of ultraviolet B (UVB) radiation and age of onset of bipolar disorder
Document Type
article
Author
Michael Bauer; Tasha Glenn; Eric D. Achtyes; Martin Alda; Esen Agaoglu; Kürsat Altınbaş; Ole A. Andreassen; Elias Angelopoulos; Raffaella Ardau; Memduha Aydin; Yavuz Ayhan; Christopher Baethge; Rita Bauer; Bernhard T. Baune; Ceylan Balaban; Claudia Becerra-Palars; Aniruddh P. Behere; Prakash B. Behere; Habte Belete; Tilahun Belete; Gabriel Okawa Belizario; Frank Bellivier; Robert H. Belmaker; Francesco Benedetti; Michael Berk; Yuly Bersudsky; Şule Bicakci; Harriet Birabwa-Oketcho; Thomas D. Bjella; Conan Brady; Jorge Cabrera; Marco Cappucciati; Angela Marianne Paredes Castro; Wei-Ling Chen; Eric Y. W. Cheung; Silvia Chiesa; Marie Crowe; Alessandro Cuomo; Sara Dallaspezia; Maria Del Zompo; Pratikkumar Desai; Seetal Dodd; Bruno Etain; Andrea Fagiolini; Frederike T. Fellendorf; Ewa Ferensztajn-Rochowiak; Jess G. Fiedorowicz; Kostas N. Fountoulakis; Mark A. Frye; Pierre A. Geoffroy; Michael J. Gitlin; Ana Gonzalez-Pinto; John F. Gottlieb; Paul Grof; Bartholomeus C. M. Haarman; Hirohiko Harima; Mathias Hasse-Sousa; Chantal Henry; Lone Hoffding; Josselin Houenou; Massimiliano Imbesi; Erkki T. Isometsä; Maja Ivkovic; Sven Janno; Simon Johnsen; Flávio Kapczinski; Gregory N. Karakatsoulis; Mathias Kardell; Lars Vedel Kessing; Seong Jae Kim; Barbara König; Timur L. Kot; Michael Koval; Mauricio Kunz; Beny Lafer; Mikael Landén; Erik R. Larsen; Melanie Lenger; Rasmus W. Licht; Carlos Lopez-Jaramillo; Alan MacKenzie; Helle Østergaard Madsen; Simone Alberte Kongstad A. Madsen; Jayant Mahadevan; Agustine Mahardika; Mirko Manchia; Wendy Marsh; Monica Martinez-Cengotitabengoa; Julia Martini; Klaus Martiny; Yuki Mashima; Declan M. McLoughlin; Ybe Meesters; Ingrid Melle; Fátima Meza-Urzúa; Pavol Mikolas; Yee Ming Mok; Scott Monteith; Muthukumaran Moorthy; Gunnar Morken; Enrica Mosca; Anton A. Mozzhegorov; Rodrigo Munoz; Starlin V. Mythri; Fethi Nacef; Ravi K. Nadella; Takako Nakanotani; René Ernst Nielsen; Claire O’Donovan; Adel Omrani; Yamima Osher; Uta Ouali; Maja Pantovic-Stefanovic; Pornjira Pariwatcharakul; Joanne Petite; Johannes Petzold; Andrea Pfennig; Yolanda Pica Ruiz; Marco Pinna; Maurizio Pompili; Richard J. Porter; Danilo Quiroz; Francisco Diego Rabelo-da-Ponte; Raj Ramesar; Natalie Rasgon; Woraphat Ratta-apha; Michaela Ratzenhofer; Maria Redahan; M. S. Reddy; Andreas Reif; Eva Z. Reininghaus; Jenny Gringer Richards; Philipp Ritter; Janusz K. Rybakowski; Leela Sathyaputri; Angela M. Scippa; Christian Simhandl; Daniel Smith; José Smith; Paul W. Stackhouse; Dan J. Stein; Kellen Stilwell; Sergio Strejilevich; Kuan-Pin Su; Mythily Subramaniam; Ahmad Hatim Sulaiman; Kirsi Suominen; Andi J. Tanra; Yoshitaka Tatebayashi; Wen Lin Teh; Leonardo Tondo; Carla Torrent; Daniel Tuinstra; Takahito Uchida; Arne E. Vaaler; Eduard Vieta; Biju Viswanath; Maria Yoldi-Negrete; Oguz Kaan Yalcinkaya; Allan H. Young; Yosra Zgueb; Peter C. Whybrow
Source
International Journal of Bipolar Disorders, Vol 11, Iss 1, Pp 1-9 (2023)
Subject
Language
English
ISSN
2194-7511
Abstract
Abstract Background Sunlight contains ultraviolet B (UVB) radiation that triggers the production of vitamin D by skin. Vitamin D has widespread effects on brain function in both developing and adult brains. However, many people live at latitudes (about > 40 N or S) that do not receive enough UVB in winter to produce vitamin D. This exploratory study investigated the association between the age of onset of bipolar I disorder and the threshold for UVB sufficient for vitamin D production in a large global sample. Methods Data for 6972 patients with bipolar I disorder were obtained at 75 collection sites in 41 countries in both hemispheres. The best model to assess the relation between the threshold for UVB sufficient for vitamin D production and age of onset included 1 or more months below the threshold, family history of mood disorders, and birth cohort. All coefficients estimated at P ≤ 0.001. Results The 6972 patients had an onset in 582 locations in 70 countries, with a mean age of onset of 25.6 years. Of the onset locations, 34.0% had at least 1 month below the threshold for UVB sufficient for vitamin D production. The age of onset at locations with 1 or more months of less than or equal to the threshold for UVB was 1.66 years younger. Conclusion UVB and vitamin D may have an important influence on the development of bipolar disorder. Study limitations included a lack of data on patient vitamin D levels, lifestyles, or supplement use. More study of the impacts of UVB and vitamin D in bipolar disorder is needed to evaluate this supposition.