학술논문
Plekhg5-regulated autophagy of synaptic vesicles reveals a pathogenic mechanism in motoneuron disease
Document Type
article
Author
Patrick Lüningschrör; Beyenech Binotti; Benjamin Dombert; Peter Heimann; Angel Perez-Lara; Carsten Slotta; Nadine Thau-Habermann; Cora R. von Collenberg; Franziska Karl; Markus Damme; Arie Horowitz; Isabelle Maystadt; Annette Füchtbauer; Ernst-Martin Füchtbauer; Sibylle Jablonka; Robert Blum; Nurcan Üçeyler; Susanne Petri; Barbara Kaltschmidt; Reinhard Jahn; Christian Kaltschmidt; Michael Sendtner
Source
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
Subject
Language
English
ISSN
2041-1723
Abstract
Accumulating evidence suggests that disruption of autophagy is associated with neurodegeneration. Here the authors show that Plekhg5 acts as a GEF for Rab26, a small GTPase that promotes the autophagy of synaptic vesicles in neurons; mice lacking Plekgh5 develop late-onset motoneuron degeneration.