학술논문
Isolated small airways obstruction predicts future chronic airflow obstruction: a multinational longitudinal study
Document Type
article
Author
Andre F S Amaral; Thorarinn Gislason; Frits Franssen; Cosetta Minelli; James Potts; Christer Janson; Rune Nielsen; Andrei Malinovschi; Padukudru Anand Mahesh; Jaymini Patel; Meriam Denguezli; Parvaiz Koul; Asaad Ahmed Nafees; Peter GJ Burney; Rana Ahmed; Sonia Buist; Ben Knox-Brown; Dhiraj Agarwal; Valentina Quintero Santofimio; Najlaa Mohammed Abass; Jayaraj BS; Sanjay K Juvekar; Stefanni Nonna M Paraguas
Source
BMJ Open Respiratory Research, Vol 10, Iss 1 (2023)
Subject
Language
English
ISSN
2052-4439
Abstract
Background Chronic airflow obstruction is a key characteristic of chronic obstructive pulmonary disease. We investigated whether isolated small airways obstruction is associated with chronic airflow obstruction later in life.Methods We used longitudinal data from 3957 participants of the multinational Burden of Obstructive Lung Disease study. We defined isolated small airways obstruction using the prebronchodilator mean forced expiratory flow rate between 25% and 75% of the forced vital capacity (FVC) (FEF25–75) if a result was less than the lower limit of normal (