학술논문
Metabolomics analysis reveals a modified amino acid metabolism that correlates with altered oxygen homeostasis in COVID-19 patients
Document Type
article
Author
José C. Páez-Franco; Jiram Torres-Ruiz; Víctor A. Sosa-Hernández; Rodrigo Cervantes-Díaz; Sandra Romero-Ramírez; Alfredo Pérez-Fragoso; David E. Meza-Sánchez; Juan Manuel Germán-Acacio; José L. Maravillas-Montero; Nancy R. Mejía-Domínguez; Alfredo Ponce-de-León; Alfredo Ulloa-Aguirre; Diana Gómez-Martín; Luis Llorente
Source
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Subject
Language
English
ISSN
2045-2322
Abstract
Abstract We identified the main changes in serum metabolites associated with severe (n = 46) and mild (n = 19) COVID-19 patients by gas chromatography coupled to mass spectrometry. The modified metabolic profiles were associated to an altered amino acid catabolism in hypoxic conditions. Noteworthy, three α-hydroxyl acids of amino acid origin increased with disease severity and correlated with altered oxygen saturation levels and clinical markers of lung damage. We hypothesize that the enzymatic conversion of α-keto-acids to α- hydroxyl-acids helps to maintain NAD recycling in patients with altered oxygen levels, highlighting the potential relevance of amino acid supplementation during SARS-CoV-2 infection.