학술논문
Massively parallel reporter assays of melanoma risk variants identify MX2 as a gene promoting melanoma
Document Type
article
Author
Jiyeon Choi; Tongwu Zhang; Andrew Vu; Julien Ablain; Matthew M. Makowski; Leandro M. Colli; Mai Xu; Rebecca C. Hennessey; Jinhu Yin; Harriet Rothschild; Cathrin Gräwe; Michael A. Kovacs; Karen M. Funderburk; Myriam Brossard; John Taylor; Bogdan Pasaniuc; Raj Chari; Stephen J. Chanock; Clive J. Hoggart; Florence Demenais; Jennifer H. Barrett; Matthew H. Law; Mark M. Iles; Kai Yu; Michiel Vermeulen; Leonard I. Zon; Kevin M. Brown
Source
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Subject
Language
English
ISSN
2041-1723
Abstract
There are more than 20 known melanoma susceptibility genes. Here, using a massively parallel reporter assay, the authors identify risk-associated variants that alter gene transcription, and demonstrate that expression of one such gene, MX2, leads to the promotion of melanoma in a zebrafish model.