학술논문
Endowing universal CAR T-cell with immune-evasive properties using TALEN-gene editing
Document Type
article
Author
Sumin Jo; Shipra Das; Alan Williams; Anne-Sophie Chretien; Thomas Pagliardini; Aude Le Roy; Jorge Postigo Fernandez; Diane Le Clerre; Billal Jahangiri; Isabelle Chion-Sotinel; Sandra Rozlan; Emilie Dessez; Agnes Gouble; Mathilde Dusséaux; Roman Galetto; Aymeric Duclert; Emanuela Marcenaro; Raynier Devillier; Daniel Olive; Philippe Duchateau; Laurent Poirot; Julien Valton
Source
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
Host versus graft reaction is a major impediment to CAR-T cell immune therapy in allogeneic settings. Authors show here that CAR-T cells, engineered to be deficient in MHC I expression but to express the NK inhibitor HLA-E, are resistant to destruction by both T and NK cells of the host.