학술논문
Phosphorylated tau181 in plasma as a potential biomarker for Alzheimer’s disease in adults with Down syndrome
Document Type
article
Author
Alberto Lleó; Henrik Zetterberg; Jordi Pegueroles; Thomas K. Karikari; María Carmona-Iragui; Nicholas J. Ashton; Victor Montal; Isabel Barroeta; Juan Lantero-Rodríguez; Laura Videla; Miren Altuna; Bessy Benejam; Susana Fernandez; Silvia Valldeneu; Diana Garzón; Alexandre Bejanin; Maria Florencia Iulita; Valle Camacho; Santiago Medrano-Martorell; Olivia Belbin; Jordi Clarimon; Sylvain Lehmann; Daniel Alcolea; Rafael Blesa; Kaj Blennow; Juan Fortea
Source
Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
Plasma tau phosphorylated at threonine 181 (p-tau181) predicts Alzheimer’s disease (AD) pathology. Here, the authors investigated whether plasma ptau181 could be a potential biomarker of AD in individuals with Down syndrome (DS) and find plasma p-tau181 can detect AD in DS adults.