학술논문
Lupus enhancer risk variant causes dysregulation of IRF8 through cooperative lncRNA and DNA methylation machinery
Document Type
article
Author
Tian Zhou; Xinyi Zhu; Zhizhong Ye; Yong-Fei Wang; Chao Yao; Ning Xu; Mi Zhou; Jianyang Ma; Yuting Qin; Yiwei Shen; Yuanjia Tang; Zhihua Yin; Hong Xu; Yutong Zhang; Xiaoli Zang; Huihua Ding; Wanling Yang; Ya Guo; John B. Harley; Bahram Namjou; Kenneth M. Kaufman; Leah C. Kottyan; Matthew T. Weirauch; Guojun Hou; Nan Shen
Source
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
The functional effects of genetic loci associated with autoimmune disease are not well understood. By dissecting an autoimmune disease genetic locus, the authors define an immune cell-type-specific enhancer and the molecular mechanisms underlying the dysregulation of IRF8 expression by lupus risk variants.