학술논문
Randomized Controlled Trial of Hospital-Based Hygiene and Water Treatment Intervention (CHoBI7) to Reduce Cholera
Document Type
article
Author
Christine Marie George; Shirajum Monira; David A. Sack; Mahamud-ur Rashid; K.M. Saif-Ur-Rahman; Toslim Mahmud; Zillur Rahman; Munshi Mustafiz; Sazzadul Islam Bhuyian; Peter J. Winch; Elli Leontsini; Jamie Perin; Farzana Begum; Fatema Zohura; Shwapon Biswas; Tahmina Parvin; Xiaotong Zhang; Danielle Jung; R. Bradley Sack; Munirul Alam
Source
Emerging Infectious Diseases, Vol 22, Iss 2, Pp 233-241 (2016)
Subject
Language
English
ISSN
1080-6040
1080-6059
1080-6059
Abstract
The risk for cholera infection is >100 times higher for household contacts of cholera patients during the week after the index patient seeks hospital care than it is for the general population. To initiate a standard of care for this high-risk population, we developed Cholera-Hospital-Based-Intervention-for-7-Days (CHoBI7), which promotes hand washing with soap and treatment of water. To test CHoBI7, we conducted a randomized controlled trial among 219 intervention household contacts of 82 cholera patients and 220 control contacts of 83 cholera patients in Dhaka, Bangladesh, during 2013–2014. Intervention contacts had significantly fewer symptomatic Vibrio cholerae infections than did control contacts and 47% fewer overall V. cholerae infections. Intervention households had no stored drinking water with V. cholerae and 14 times higher odds of hand washing with soap at key events during structured observation on surveillance days 5, 6, or 7. CHoBI7 presents a promising approach for controlling cholera among highly susceptible household contacts of cholera patients.