학술논문
SCIPAC: quantitative estimation of cell-phenotype associations
Document Type
article
Author
Source
Genome Biology, Vol 25, Iss 1, Pp 1-23 (2024)
Subject
Language
English
ISSN
1474-760X
Abstract
Abstract Numerous algorithms have been proposed to identify cell types in single-cell RNA sequencing data, yet a fundamental problem remains: determining associations between cells and phenotypes such as cancer. We develop SCIPAC, the first algorithm that quantitatively estimates the association between each cell in single-cell data and a phenotype. SCIPAC also provides a p-value for each association and applies to data with virtually any type of phenotype. We demonstrate SCIPAC’s accuracy in simulated data. On four real cancerous or noncancerous datasets, insights from SCIPAC help interpret the data and generate new hypotheses. SCIPAC requires minimum tuning and is computationally very fast.