부산대학교 도서관

AbstractBackground Knowledge about the influence of early developmental factors on cardiometabolic health in the Maya is limited.Aim To analyse the relationship between birthweight (BW) and cardiometabolic parameters in a sample of rural Maya children from Yucatan, Mexico.Subjects and methods We took anthropometric measurements and obtained data on BW and fasting blood samples in a sample of 75 children aged 5–14 years. Dependent variables were: fat mass index (FMI), body mass index (BMI), glucose (G), triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol (LDL), LDL/HDL and TC/HDL ratios and metabolic index (TGxG/HDL2). Outcomes were transformed to y = 100 log(e)x and the resulting estimates are interpreted as symmetrical percentage differences. The main independent variable was BW z-score. Multiple linear regression analyses were used to assess the relationship between BW and outcomes.Results An increase of one standard deviation in BW predicted 6.6% (95% CI [–11.6, −1.6]) decrease in HDL and 11% (95% CI [3.7, 18.4]), 7.8% (95% CI [2.3, 13.2]) and 19.6% (95% CI [3.1, 36]) increases in LDL/HDL, TC/HDL and metabolic index, respectively.Conclusion Higher birthweights were associated with adverse levels of biochemical parameters in this sample of rural Maya children.