학술논문
Aging-related aneuploidy is associated with mitochondrial imbalance and failure of spindle assembly
Document Type
article
Author
Source
Cell Death Discovery, Vol 9, Iss 1, Pp 1-12 (2023)
Subject
Language
English
ISSN
2058-7716
Abstract
Abstract Despite aging is closely linked to increased aneuploidy in the oocytes, the mechanism of how aging affects aneuploidy remains largely elusive. Here, we applied single-cell parallel methylation and transcriptome sequencing (scM&T-seq) data from the aging mouse oocyte model to decode the genomic landscape of oocyte aging. We found a decline in oocyte quality in aging mice, as manifested by a significantly lower rate of first polar body exclusion (P