학술논문
Human amnion epithelial cell therapy reduces hypertension-induced vascular stiffening and cognitive impairment
Document Type
article
Author
Quynh Nhu Dinh; Cecilia Lo; David Wong Zhang; Vivian Tran; Tayla Gibson-Hughes; Ashleigh Sheriff; Henry Diep; Hyun Ah Kim; Shenpeng R. Zhang; Liz J. Barreto-Arce; Maria Jelinic; Antony Vinh; Thiruma V. Arumugam; Siow Teng Chan; Rebecca Lim; Grant R. Drummond; Christopher G. Sobey; T. Michael De Silva
Source
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Subject
Language
English
ISSN
2045-2322
Abstract
Abstract Vascular inflammation and fibrosis are hallmarks of hypertension and contribute to the development of cardiovascular disease and cognitive impairment. However, current anti-hypertensive drugs do not treat the underlying tissue damage, such as inflammation-associated fibrosis. Human amnion epithelial cells have several properties amenable for treating vascular pathology. This study tested the effect of amnion epithelial cells on vascular pathology and cognitive impairment during hypertension. Male C57Bl6 mice (8–12 weeks) were administered vehicle (saline; n = 58) or angiotensin II (0.7 mg/kg/d, n = 56) subcutaneously for 14 d. After surgery, a subset of mice were injected with 106 amnion epithelial cells intravenously. Angiotensin II infusion increased systolic blood pressure, aortic pulse wave velocity, accumulation of aortic leukocytes, and aortic mRNA expression of collagen subtypes compared to vehicle-infused mice (n = 9–11, P