학술논문
Simple cardiovascular risk stratification by replacing total serum cholesterol with anthropometric measures: The MORGAM prospective cohort project
Document Type
article
Author
Victoria Rosberg; Julie KK Vishram-Nielsen; Anna M. Dyrvig Kristensen; Manan Pareek; Thomas S.G. Sehested; Peter M Nilsson; Allan Linneberg; Luigi Palmieri; Simona Giampaoli; Chiara Donfrancesco; Frank Kee; Giuseppe Mancia; Giancarlo Cesana; Giovanni Veronesi; Guido Grassi; Kari Kuulasmaa; Veikko Salomaa; Tarja Palosaari; Susana Sans; Jean Ferrieres; Jean Dallongeville; Stefan Söderberg; Marie Moitry; Wojciech Drygas; Abdonas Tamosiunas; Annette Peters; Hermann Brenner; Ben Schöttker; Sameline Grimsgaard; Tor Biering-Sørensen; Michael H Olsen
Source
Preventive Medicine Reports, Vol 26, Iss , Pp 101700- (2022)
Subject
Language
English
ISSN
2211-3355
Abstract
To assess whether anthropometric measures (body mass index [BMI], waist-hip ratio [WHR], and estimated fat mass [EFM]) are independently associated with major adverse cardiovascular events (MACE), and to assess their added prognostic value compared with serum total-cholesterol. The study population comprised 109,509 individuals (53% men) from the MORGAM-Project, aged 19–97 years, without established cardiovascular disease, and not on antihypertensive treatment. While BMI was reported in all, WHR and EFM were reported in ∼52,000 participants. Prognostic importance of anthropometric measurements and total-cholesterol was evaluated using adjusted Cox proportional-hazards regression, logistic regression, area under the receiver-operating-characteristic curve (AUCROC), and net reclassification improvement (NRI). The primary endpoint was MACE, a composite of stroke, myocardial infarction, or death from coronary heart disease. Age interacted significantly with anthropometric measures and total-cholesterol on MACE (P ≤ 0.003), and therefore age-stratified analyses (