학술논문
Effects and mechanisms of kidney bean peptides on uric-lowering activity in oteracil potassium-induced hyperuricemia rats
Document Type
article
Author
Source
Journal of Functional Foods, Vol 116, Iss , Pp 106172- (2024)
Subject
Language
English
ISSN
1756-4646
Abstract
In the present study, the stability of kidney bean-derived DWYDIK (Asp-Trp-Tyr-Asp-Ile-Lys) after acid and alkali treatment and in vitro simulated gastrointestinal digestion were determined. Next, the uric acid-lowering activity and mechanisms of kidney bean peptides (KBPs) and DWYDIK were studied in vivo. We found that DWYDIK had certain tolerance to digestive enzymes. KBPs and DWYDIK significantly inhibited the activity of xanthine oxidase, reduced creatinine content, improved the changes of glomerular morphological, cellular vacuolar degeneration and inflammatory cell infiltration in kidney, and recovered intestinal tissue damages in hyperuricemia rats (p