학술논문
14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function
Document Type
article
Author
Simone M. Schoenwaelder; Roxane Darbousset; Susan L. Cranmer; Hayley S. Ramshaw; Stephanie L. Orive; Sharelle Sturgeon; Yuping Yuan; Yu Yao; James R. Krycer; Joanna Woodcock; Jessica Maclean; Stuart Pitson; Zhaohua Zheng; Darren C. Henstridge; Dianne van der Wal; Elizabeth E. Gardiner; Michael C. Berndt; Robert K. Andrews; David E. James; Angel F. Lopez; Shaun P. Jackson
Source
Nature Communications, Vol 7, Iss 1, Pp 1-17 (2016)
Subject
Language
English
ISSN
2041-1723
Abstract
Platelets express negatively charged phosphatidylserine (PS) on their plasma membrane when propagating coagulation within a developing thrombus. Here the authors show that an adaptor protein 14-3-3 regulates mitochondrial function and PS exposure and thus platelet procoagulant activity, promising a new therapy to reduce thrombosis.