학술논문
Compression force sensing regulates integrin αIIbβ3 adhesive function on diabetic platelets
Document Type
article
Author
Source
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Subject
Language
English
ISSN
2041-1723
Abstract
Diabetes is associated with an increased thrombotic response, but the mechanism is unknown. Here the authors demonstrate that compressive force activates integrin αIIbβ3 on discoid diabetic platelets and that platelet aggregates can be eliminated by PI 3-kinase inhibition, but not by anti-thrombotics aspirin or clopidogrel.