학술논문
The epichaperome is a mediator of toxic hippocampal stress and leads to protein connectivity-based dysfunction
Document Type
article
Author
Maria Carmen Inda; Suhasini Joshi; Tai Wang; Alexander Bolaender; Srinivasa Gandu; John Koren III; Alicia Yue Che; Tony Taldone; Pengrong Yan; Weilin Sun; Mohammad Uddin; Palak Panchal; Matthew Riolo; Smit Shah; Afsar Barlas; Ke Xu; Lon Yin L. Chan; Alexandra Gruzinova; Sarah Kishinevsky; Lorenz Studer; Valentina Fossati; Scott A. Noggle; Julie R. White; Elisa de Stanchina; Sonia Sequeira; Kyle H. Anthoney; John W. Steele; Katia Manova-Todorova; Sujata Patil; Mark P. Dunphy; NagaVaraKishore Pillarsetty; Ana C. Pereira; Hediye Erdjument-Bromage; Thomas A. Neubert; Anna Rodina; Stephen D. Ginsberg; Natalia De Marco Garcia; Wenjie Luo; Gabriela Chiosis
Source
Nature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
Subject
Language
English
ISSN
2041-1723
Abstract
The biology of Alzheimer’s disease (AD) remains unknown. We propose AD is a protein connectivity-based dysfunction disorder whereby a switch of the chaperome into epichaperomes rewires proteome-wide connectivity, leading to brain circuitry malfunction that can be corrected by novel therapeutics.