학술논문
Therapeutic targeting of the PLK1-PRC1-axis triggers cell death in genomically silent childhood cancer
Document Type
article
Author
Jing Li; Shunya Ohmura; Aruna Marchetto; Martin F. Orth; Roland Imle; Marlene Dallmayer; Julian Musa; Maximilian M. L. Knott; Tilman L. B. Hölting; Stefanie Stein; Cornelius M. Funk; Ana Sastre; Javier Alonso; Felix Bestvater; Merve Kasan; Laura Romero-Pérez; Wolfgang Hartmann; Andreas Ranft; Ana Banito; Uta Dirksen; Thomas Kirchner; Florencia Cidre-Aranaz; Thomas G. P. Grünewald
Source
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
In this study, the authors show that that oncogenic hijacking of PRC1 sensitizes genomically stable Ewing sarcoma cells for PLK1 inhibition alone or in synergy with a microtubule-destabilizing drug via induction of cytokinesis defects, rendering PRC1 a promising, broadly applicable predictive biomarker