학술논문
Effects of Varicocele Repair on Sperm DNA Fragmentation and Seminal Malondialdehyde Levels in Infertile Men with Clinical Varicocele: A Systematic Review and Meta-Analysis
Document Type
article
Author
Rossella Cannarella; Rupin Shah; Ramadan Saleh; Florence Boitrelle; Taha Abo-Almagd Abdel-Meguid Hamoda; Rajender Singh; Gianmaria Salvio; Tuncay Toprak; Marco Falcone; Murat Gul; Fotios Dimitriadis; Amarnath Rambhatla; Giorgio I. Russo; Edmund Ko; Armand Zini; Parviz Kavoussi; Nguyen Ho Vinh Phuoc; Hussein Kandil; Ramy Abou Ghayda; Ponco Birowo; Nazim Gherabi; Erman Ceyhan; Jie Dong; Vineet Malhotra; Damayanthi Durairajanayagam; Bircan Kolbasi; Fahmi Bahar; Gokhan Calik; Selahittin Çayan; Germar-Michael Pinggera; Aldo E. Calogero; Osvaldo Rajmil; Taymour Mostafa; Widi Atmoko; Ahmed M. Harraz; Tan V. Le; Jean de la Rosette; Lukman Hakim; Edoardo Pescatori; Oleg Sergeyev; Ayman Rashed; Pallavi Saini; Ashok Agarwal
Source
The World Journal of Men's Health, Vol 42, Iss 2, Pp 321-337 (2024)
Subject
Language
English
ISSN
2287-4208
2287-4690
2287-4690
Abstract
Purpose: Varicoceles can be a source of elevated seminal oxidative stress (OS) and sperm DNA fragmentation (SDF). However, it remains unclear whether varicocele repair (VR) could reduce these parameters. This systematic review and metaanalysis (SRMA) aims to investigate the impact of VR on SDF and seminal malondialdehyde (MDA). Materials and Methods: A literature search was performed in Scopus, PubMed, Ovid, Embase, and Cochrane databases. This SRMA included randomized controlled trials and observational studies reporting the pre- and postoperative levels of SDF and seminal OS in infertile men with clinical varicocele that underwent VR. Subgroup analyses included techniques of VR and SDF testing. The effect size was expressed as standardized mean difference (SMD). Results: Out of 1,632 abstracts assessed for eligibility, 29 studies with 1,491 infertile men were included. The analysis showed a significant reduction in SDF after VR, compared to preoperative values (SMD –1.125, 95% confidence interval [CI] –1.410, –0.840; p