학술논문
Calcium-sensing receptor-mediated NLRP3 inflammasome response to calciprotein particles drives inflammation in rheumatoid arthritis
Document Type
article
Author
Elisabeth Jäger; Supriya Murthy; Caroline Schmidt; Magdalena Hahn; Sarah Strobel; Anna Peters; Claudia Stäubert; Pelin Sungur; Tom Venus; Mandy Geisler; Veselina Radusheva; Stefanie Raps; Kathrin Rothe; Roger Scholz; Sebastian Jung; Sylke Wagner; Matthias Pierer; Olga Seifert; Wenhan Chang; Irina Estrela-Lopis; Nora Raulien; Knut Krohn; Norbert Sträter; Stephanie Hoeppener; Torsten Schöneberg; Manuela Rossol; Ulf Wagner
Source
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Subject
Language
English
ISSN
2041-1723
Abstract
How extracellular calcium can trigger Nlrp3 inflammasome activation has been somewhat controversial and unclear. Here the authors show calciprotein particles are taken up by myeloid cells via calcium-sensing receptor-dependent macropinocytosis in response to high levels of extracellular Ca2+ and this pathway might be critical to inflammatory conditions.