학술논문
Delayed induction of type I and III interferons mediates nasal epithelial cell permissiveness to SARS-CoV-2
Document Type
article
Author
Catherine F. Hatton; Rachel A. Botting; Maria Emilia Dueñas; Iram J. Haq; Bernard Verdon; Benjamin J. Thompson; Jarmila Stremenova Spegarova; Florian Gothe; Emily Stephenson; Aaron I. Gardner; Sandra Murphy; Jonathan Scott; James P. Garnett; Sean Carrie; Jason Powell; C. M. Anjam Khan; Lei Huang; Rafiqul Hussain; Jonathan Coxhead; Tracey Davey; A. John Simpson; Muzlifah Haniffa; Sophie Hambleton; Malcolm Brodlie; Chris Ward; Matthias Trost; Gary Reynolds; Christopher J. A. Duncan
Source
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
The innate immune response in epithelial cells after SARS-CoV-2 infection is not fully understood. Here the authors use human air-liquid interface culture and show single cell transcription changes and delayed type I Interferon responses after SARS-CoV-2 infection compared with other respiratory viruses.