학술논문
International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci
Document Type
article
Author
Caroline M. Nievergelt; Adam X. Maihofer; Torsten Klengel; Elizabeth G. Atkinson; Chia-Yen Chen; Karmel W. Choi; Jonathan R. I. Coleman; Shareefa Dalvie; Laramie E. Duncan; Joel Gelernter; Daniel F. Levey; Mark W. Logue; Renato Polimanti; Allison C. Provost; Andrew Ratanatharathorn; Murray B. Stein; Katy Torres; Allison E. Aiello; Lynn M. Almli; Ananda B. Amstadter; Søren B. Andersen; Ole A. Andreassen; Paul A. Arbisi; Allison E. Ashley-Koch; S. Bryn Austin; Esmina Avdibegovic; Dragan Babić; Marie Bækvad-Hansen; Dewleen G. Baker; Jean C. Beckham; Laura J. Bierut; Jonathan I. Bisson; Marco P. Boks; Elizabeth A. Bolger; Anders D. Børglum; Bekh Bradley; Megan Brashear; Gerome Breen; Richard A. Bryant; Angela C. Bustamante; Jonas Bybjerg-Grauholm; Joseph R. Calabrese; José M. Caldas- de- Almeida; Anders M. Dale; Mark J. Daly; Nikolaos P. Daskalakis; Jürgen Deckert; Douglas L. Delahanty; Michelle F. Dennis; Seth G. Disner; Katharina Domschke; Alma Dzubur-Kulenovic; Christopher R. Erbes; Alexandra Evans; Lindsay A. Farrer; Norah C. Feeny; Janine D. Flory; David Forbes; Carol E. Franz; Sandro Galea; Melanie E. Garrett; Bizu Gelaye; Elbert Geuze; Charles Gillespie; Aferdita Goci Uka; Scott D. Gordon; Guia Guffanti; Rasha Hammamieh; Supriya Harnal; Michael A. Hauser; Andrew C. Heath; Sian M. J. Hemmings; David Michael Hougaard; Miro Jakovljevic; Marti Jett; Eric Otto Johnson; Ian Jones; Tanja Jovanovic; Xue-Jun Qin; Angela G. Junglen; Karen-Inge Karstoft; Milissa L. Kaufman; Ronald C. Kessler; Alaptagin Khan; Nathan A. Kimbrel; Anthony P. King; Nastassja Koen; Henry R. Kranzler; William S. Kremen; Bruce R. Lawford; Lauren A. M. Lebois; Catrin E. Lewis; Sarah D. Linnstaedt; Adriana Lori; Bozo Lugonja; Jurjen J. Luykx; Michael J. Lyons; Jessica Maples-Keller; Charles Marmar; Alicia R. Martin; Nicholas G. Martin; Douglas Maurer; Matig R. Mavissakalian; Alexander McFarlane; Regina E. McGlinchey; Katie A. McLaughlin; Samuel A. McLean; Sarah McLeay; Divya Mehta; William P. Milberg; Mark W. Miller; Rajendra A. Morey; Charles Phillip Morris; Ole Mors; Preben B. Mortensen; Benjamin M. Neale; Elliot C. Nelson; Merete Nordentoft; Sonya B. Norman; Meaghan O’Donnell; Holly K. Orcutt; Matthew S. Panizzon; Edward S. Peters; Alan L. Peterson; Matthew Peverill; Robert H. Pietrzak; Melissa A. Polusny; John P. Rice; Stephan Ripke; Victoria B. Risbrough; Andrea L. Roberts; Alex O. Rothbaum; Barbara O. Rothbaum; Peter Roy-Byrne; Ken Ruggiero; Ariane Rung; Bart P. F. Rutten; Nancy L. Saccone; Sixto E. Sanchez; Dick Schijven; Soraya Seedat; Antonia V. Seligowski; Julia S. Seng; Christina M. Sheerin; Derrick Silove; Alicia K. Smith; Jordan W. Smoller; Scott R. Sponheim; Dan J. Stein; Jennifer S. Stevens; Jennifer A. Sumner; Martin H. Teicher; Wesley K. Thompson; Edward Trapido; Monica Uddin; Robert J. Ursano; Leigh Luella van den Heuvel; Miranda Van Hooff; Eric Vermetten; Christiaan H. Vinkers; Joanne Voisey; Yunpeng Wang; Zhewu Wang; Thomas Werge; Michelle A. Williams; Douglas E. Williamson; Sherry Winternitz; Christiane Wolf; Erika J. Wolf; Jonathan D. Wolff; Rachel Yehuda; Ross McD. Young; Keith A. Young; Hongyu Zhao; Lori A. Zoellner; Israel Liberzon; Kerry J. Ressler; Magali Haas; Karestan C. Koenen
Source
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Subject
Language
English
ISSN
2041-1723
Abstract
Post-traumatic stress disorder (PTSD) is a common mental health problem. Here, the authors report a GWAS from the Psychiatric Genomics Consortium in which they identify two risk loci in European ancestry and one locus in African ancestry individuals and find that PTSD is genetically correlated with several other psychiatric traits.