학술논문
Substance Use and Adherence to HIV Preexposure Prophylaxis for Men Who Have Sex with Men
Document Type
article
Author
Source
Emerging Infectious Diseases, Vol 24, Iss 12, Pp 2292-2302 (2018)
Subject
Language
English
ISSN
1080-6040
1080-6059
1080-6059
Abstract
The effectiveness of oral HIV preexposure prophylaxis (PrEP) strongly depends on maintaining adherence. We investigated the association between substance use and PrEP adherence, as well as incident sexually transmitted infections (STIs) in a high-risk cohort of 394 participants (391 men who have sex with men and 3 transgender women) who were enrolled in a PrEP demonstration project. We assessed baseline and ongoing substance use over a 48-week period for stimulants and nonstimulant substances and for each substance separately. We measured PrEP adherence by using dried blood spots to obtain levels of tenofovir diphosphate. No differences in these levels were found between substance users and nonsubstance users. Baseline stimulant use was strongly associated (odds ratio 3.4; p