학술논문
Expression quantitative trait methylation analysis elucidates gene regulatory effects of DNA methylation: the Framingham Heart Study
Document Type
article
Author
Amena Keshawarz; Helena Bui; Roby Joehanes; Jiantao Ma; Chunyu Liu; Tianxiao Huan; Shih-Jen Hwang; Brandon Tejada; Meera Sooda; Paul Courchesne; Peter J. Munson; Cumhur Y. Demirkale; Chen Yao; Nancy L. Heard-Costa; Achilleas N. Pitsillides; Honghuang Lin; Ching-Ti Liu; Yuxuan Wang; Gina M. Peloso; Jessica Lundin; Jeffrey Haessler; Zhaohui Du; Michael Cho; Craig P. Hersh; Peter Castaldi; Laura M. Raffield; Jia Wen; Yun Li; Alexander P. Reiner; Mike Feolo; Nataliya Sharopova; Ramachandran S. Vasan; Dawn L. DeMeo; April P. Carson; Charles Kooperberg; Daniel Levy
Source
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Subject
Language
English
ISSN
2045-2322
Abstract
Abstract Expression quantitative trait methylation (eQTM) analysis identifies DNA CpG sites at which methylation is associated with gene expression. The present study describes an eQTM resource of CpG-transcript pairs derived from whole blood DNA methylation and RNA sequencing gene expression data in 2115 Framingham Heart Study participants. We identified 70,047 significant cis CpG-transcript pairs at p