학술논문
Intestinal non-canonical NFκB signaling shapes the local and systemic immune response
Document Type
article
Author
Sadeesh K. Ramakrishnan; Huabing Zhang; Xiaoya Ma; Inkyung Jung; Andrew J. Schwartz; Daniel Triner; Samantha N. Devenport; Nupur K. Das; Xiang Xue; Melody Y. Zeng; Yinling Hu; Richard M. Mortensen; Joel K Greenson; Marilia Cascalho; Christiane E. Wobus; Justin A. Colacino; Gabriel Nunez; Liangyou Rui; Yatrik M. Shah
Source
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Subject
Language
English
ISSN
2041-1723
Abstract
Microfold cells (M-cell) are specialized cells of the intestine that sample luminal microbiota and dietary antigens. Here the authors show that epithelial non-canonical NFκB signalling, as induced by NIK, is important for M-cells maintenance, yet constitutive NIK activation is associated with gut inflammation and inflammatory bowel disease.