학술논문
Genome-wide association study in frontal fibrosing alopecia identifies four susceptibility loci including HLA-B*07:02
Document Type
article
Author
Christos Tziotzios; Christos Petridis; Nick Dand; Chrysanthi Ainali; Jake R. Saklatvala; Venu Pullabhatla; Alexandros Onoufriadis; Rashida Pramanik; David Baudry; Sang Hyuck Lee; Kristie Wood; Lu Liu; Seth Seegobin; Gregory A. Michelotti; Su M. Lwin; Evangelos A. A. Christou; Charles J. Curtis; Emanuele de Rinaldis; Alka Saxena; Susan Holmes; Matthew Harries; Ioulios Palamaras; Fiona Cunningham; Gregory Parkins; Manjit Kaur; Paul Farrant; Andrew McDonagh; Andrew Messenger; Jennifer Jones; Victoria Jolliffe; Iaisha Ali; Michael Ardern-Jones; Charles Mitchell; Nigel Burrows; Ravinder Atkar; Cedric Banfield; Anton Alexandroff; Caroline Champagne; Hywel L. Cooper; Sergio Vañó-Galván; Ana Maria Molina-Ruiz; Nerea Ormaechea Perez; Girish K. Patel; Abby Macbeth; Melanie Page; Alyson Bryden; Megan Mowbray; Shyamal Wahie; Keith Armstrong; Nicola Cooke; Mark Goodfield; Irene Man; David de Berker; Giles Dunnill; Anita Takwale; Archana Rao; Tee-Wei Siah; Rodney Sinclair; Martin S. Wade; Ncoza C. Dlova; Jane Setterfield; Fiona Lewis; Kapil Bhargava; Niall Kirkpatrick; Xavier Estivill; Catherine M. Stefanato; Carsten Flohr; Timothy Spector; Fiona M. Watt; Catherine H. Smith; Jonathan N. Barker; David A. Fenton; Michael A. Simpson; John A. McGrath
Source
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
Subject
Language
English
ISSN
2041-1723
Abstract
Frontal fibrosing alopecia (FFA) features lichenoid cutaneous inflammation and scarring hair loss. Here, Tziotzios et al. identify four genetic loci associated with FFA by GWAS followed by Bayesian fine-mapping, co-localisation and HLA imputation which highlights HLA-B*07:02 as a risk factor.