학술논문
Defective viral genomes as therapeutic interfering particles against flavivirus infection in mammalian and mosquito hosts
Document Type
article
Author
Veronica V. Rezelj; Lucía Carrau; Fernando Merwaiss; Laura I. Levi; Diana Erazo; Quang Dinh Tran; Annabelle Henrion-Lacritick; Valérie Gausson; Yasutsugu Suzuki; Djoshkun Shengjuler; Bjoern Meyer; Thomas Vallet; James Weger-Lucarelli; Veronika Bernhauerová; Avi Titievsky; Vadim Sharov; Stefano Pietropaoli; Marco A. Diaz-Salinas; Vincent Legros; Nathalie Pardigon; Giovanna Barba-Spaeth; Leonid Brodsky; Maria-Carla Saleh; Marco Vignuzzi
Source
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
Defective viral genomes (DVGs) can interfere with virus replication and provide a potential approach to control infection. Here, Rezelj et al. use a combined experimental evolution and computational approach to identify DVG sequences that optimally interfere with Zika virus infection and show antiviral activity in mice and mosquitoes.