학술논문
TLCD1 and TLCD2 regulate cellular phosphatidylethanolamine composition and promote the progression of non-alcoholic steatohepatitis
Document Type
article
Author
Kasparas Petkevicius; Henrik Palmgren; Matthew S. Glover; Andrea Ahnmark; Anne-Christine Andréasson; Katja Madeyski-Bengtson; Hiroki Kawana; Erik L. Allman; Delaney Kaper; Martin Uhrbom; Liselotte Andersson; Leif Aasehaug; Johan Forsström; Simonetta Wallin; Ingela Ahlstedt; Renata Leke; Daniel Karlsson; Hernán González-King; Lars Löfgren; Ralf Nilsson; Giovanni Pellegrini; Nozomu Kono; Junken Aoki; Sonja Hess; Grzegorz Sienski; Marc Pilon; Mohammad Bohlooly-Y; Marcello Maresca; Xiao-Rong Peng
Source
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Subject
Language
English
ISSN
2041-1723
15464563
15464563
Abstract
The regulation of cellular phosphatidylethanolamine (PE) acyl chain composition is poorly understood. Here, the authors show that TLCD1 and TLCD2 proteins mediate the formation of monounsaturated fatty acid-containing PE species and promote the progression of non-alcoholic steatohepatitis.