학술논문
Thymopoiesis in Pre- and Post-Hematopoietic Stem Cell Transplantation
Document Type
article
Author
Luis Klaus A. da Rocha; Samar Freschi de Barros; Francine Bandeira; Alexia Bollini; Lucia Helena de A. Testa; Anderson João Simione; Marina de O. e Souza; Lilian P. Zanetti; Leila Cibele S. de Oliveira; Ana Claúdia F. dos Santos; Mair Pedro de Souza; Vergílio Antônio R. Colturado; Jorge Kalil; Clarisse M. Machado; Luiza Guilherme
Source
Frontiers in Immunology, Vol 9 (2018)
Subject
Language
English
ISSN
1664-3224
Abstract
Hematopoietic stem cell transplantation (HSCT) is an important therapeutic option for some hematological diseases. However, patients who undergo HSCT acquire a state of immunodeficiency that causes significant mortality. Reconstitution of thymic function is needed to support the immune system. One way to measure thymic function is through T-cell receptor excision circle (TREC) quantification. TRECs are generated by T-cell receptor gene rearrangements during T-cell maturation in the thymus and represent a reliable marker for thymic output. In this study, we aimed to assess aging and malignant hematological diseases as two important factors that may influence thymic output before HSCT. We observed that patients before HSCT presented signal joint TREC (sjTREC) numbers lower than 606.55 copies/μg DNA (low values) compared with healthy individuals, with an odds ratio (OR) of 12.88 [95% confidence interval (CI): 5.26–31.53; p