학술논문
Epigenetic control of melanoma cell invasiveness by the stem cell factor SALL4
Document Type
article
Author
Source
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
Melanoma cells can switch between proliferative and invasive phenotypes. Here the authors show that the embryonic stem cell factor Sall4 is a negative regulator of melanoma phenotype switching where its loss leads to the acquisition of an invasive phenotype, due to derepression of invasiveness genes.