학술논문
Myelodysplastic Syndrome associated TET2 mutations affect NK cell function and genome methylation
Document Type
article
Author
Maxime Boy; Valeria Bisio; Lin-Pierre Zhao; Fabien Guidez; Bérénice Schell; Emilie Lereclus; Guylaine Henry; Juliette Villemonteix; Fernando Rodrigues-Lima; Katia Gagne; Christelle Retiere; Lise Larcher; Rathana Kim; Emmanuelle Clappier; Marie Sebert; Arsène Mekinian; Olivier Fain; Anne Caignard; Marion Espeli; Karl Balabanian; Antoine Toubert; Pierre Fenaux; Lionel Ades; Nicolas Dulphy
Source
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Subject
Language
English
ISSN
2041-1723
Abstract
Myelodysplastic syndromes are characterised by clonal haematopoiesis, with the affected cells often harbouring mutations in the TET2 gene, an important regulator of DNA methylation state. Here authors show that the same mutations are also found in NK cells, perturbing their DNA methylation pattern and cytolytic function.