학술논문
Genomic programming of IRF4-expressing human Langerhans cells
Document Type
article
Author
Sofia Sirvent; Andres F. Vallejo; James Davies; Kalum Clayton; Zhiguo Wu; Jeongmin Woo; Jeremy Riddell; Virendra K. Chaudhri; Patrick Stumpf; Liliya Angelova Nazlamova; Gabrielle Wheway; Matthew Rose-Zerilli; Jonathan West; Mario Pujato; Xiaoting Chen; Christopher H. Woelk; Ben MacArthur; Michael Ardern-Jones; Peter S. Friedmann; Matthew T. Weirauch; Harinder Singh; Marta E. Polak
Source
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Subject
Language
English
ISSN
2041-1723
Abstract
Langerhans cells (LC) can prime tolerogenic as well as immunogenic responses in the skin. Here the authors show, by transcriptomic, epigenetic and CRISPR editing analyses, that during LC migration and maturation the transcription factor IRF4 regulates expression of antigen presentation and co-stimulatory gene modules while attenuating inflammatory response genes.