학술논문
Gut microbiome and atrial fibrillation—results from a large population-based studyResearch in context
Document Type
article
Author
Joonatan Palmu; Christin S. Börschel; Alfredo Ortega-Alonso; Lajos Markó; Michael Inouye; Pekka Jousilahti; Rodolfo A. Salido; Karenina Sanders; Caitriona Brennan; Gregory C. Humphrey; Jon G. Sanders; Friederike Gutmann; Dominik Linz; Veikko Salomaa; Aki S. Havulinna; Sofia K. Forslund; Rob Knight; Leo Lahti; Teemu Niiranen; Renate B. Schnabel
Source
EBioMedicine, Vol 91, Iss , Pp 104583- (2023)
Subject
Language
English
ISSN
2352-3964
Abstract
Summary: Background: Atrial fibrillation (AF) is an important heart rhythm disorder in aging populations. The gut microbiome composition has been previously related to cardiovascular disease risk factors. Whether the gut microbial profile is also associated with the risk of AF remains unknown. Methods: We examined the associations of prevalent and incident AF with gut microbiota in the FINRISK 2002 study, a random population sample of 6763 individuals. We replicated our findings in an independent case–control cohort of 138 individuals in Hamburg, Germany. Findings: Multivariable-adjusted regression models revealed that prevalent AF (N = 116) was associated with nine microbial genera. Incident AF (N = 539) over a median follow-up of 15 years was associated with eight microbial genera with false discovery rate (FDR)-corrected P