학술논문
Successful Multimodal Treatment of Intracranial Growing Teratoma Syndrome with Malignant Features
Document Type
article
Author
Daiken Satake; Manabu Natsumeda; Kaishi Satomi; Mari Tada; Taro Sato; Noritaka Okubo; Keita Kawabe; Haruhiko Takahashi; Yoshihiro Tsukamoto; Masayasu Okada; Masakazu Sano; Haruko Iwabuchi; Nao Shibata; Masaru Imamura; Chihaya Imai; Hirokazu Takami; Koichi Ichimura; Ryo Nishikawa; Hajime Umezu; Akiyoshi Kakita; Makoto Oishi
Source
Current Oncology, Vol 31, Iss 4, Pp 1831-1838 (2024)
Subject
Language
English
ISSN
1718-7729
1198-0052
1198-0052
Abstract
Molecular analysis of the growing teratoma syndrome has not been extensively studied. Here, we report a 14-year-old boy with a growing mass during treatment for a mixed germ cell tumor of the pineal region. Tumor markers were negative; thus, growing teratoma syndrome was suspected. A radical resection via the occipital transtentorial approach was performed, and histopathological examination revealed a teratoma with malignant features. Methylation classifier analysis confirmed the diagnosis of teratoma, and DMRT1 loss and 12p gain were identified by copy number variation analysis, potentially elucidating the cause of growth and malignant transformation of the teratoma. The patient remains in remission after intense chemoradiation treatment as a high-risk germ cell tumor.