학술논문
Still’s disease continuum from childhood to elderly: data from the international AIDA Network Still’s disease registry
Document Type
article
Author
Micol Frassi; Marcello Govoni; Annamaria Iagnocco; Florenzo Iannone; Paola Triggianese; Corrado Campochiaro; Sara Monti; Maria G Tektonidou; Eduardo Martin-Nares; Piero Ruscitti; Roberto Giacomelli; Luca Cantarini; Giuseppe Lopalco; Lorenzo Dagna; Francesco Carubbi; Alma Nunzia Olivieri; Antonio Vitale; Ombretta Viapiana; Fatma Alibaz-Öner; Haner Direskeneli; Petros P Sfikakis; Giacomo Emmi; Claudia Fabiani; Gabriele Simonini; Francesco Ciccia; Elena Bartoloni; Alessandro Tomelleri; Daniela Iacono; Riza Can Kardas; Bruno Frediani; Benson Ogunjimi; Amato de Paulis; Onorina Berardicurti; Alessandro Conforti; Ilenia Di Cola; Anastasios Karamanakos; Katerina Laskari; Abdurrahman Tufan; Stefania Costi; José Hernández-Rodríguez; Lampros Fotis; Jurgen Sota; Antonio Gidaro; Ewa Wiesik-Szewczyk; Gian Domenico Sebastiani; Jiram Torres-Ruiz; Paolo Sfriso; Giovanni Conti; Luca Navarini; Francesco La Torre; Samar Tharwat; Andrea Hinojosa-Azaola; Alberto Lo Gullo; Valeria Caggiano; Ibrahim A Almaghlouth; Kazi Asfina; Gafaar Ragab; Maria Cristina Maggio; Joanna Makowska; Emanuela Del Giudice; Armin Maier; Sukran Erten; Henrique A Mayrink Giardini; Maria Morrone; Isabele Parente de Brito Antonelli; Marilia Ambiel Dagostin; Martina Patrone; Fehaid Alanazi; Carla Gaggiano; Hamit Kucuk; Ayman Abdel-Monem Ahmed Mahmoud; Katerina Kourtesi; Maria Tarsia; Verónica Gómez-Caverzaschi; Angela Mauro; Alberto Balistreri
Source
RMD Open, Vol 9, Iss 4 (2023)
Subject
Language
English
ISSN
2056-5933
Abstract
Objective Still’s disease is more frequently observed in the paediatric context, but a delayed onset is not exceptional both in the adulthood and in the elderly. However, whether paediatric-onset, adult-onset and elderly-onset Still’s disease represent expressions of the same disease continuum or different clinical entities is still a matter of controversy. The aim of this study is to search for any differences in demographic, clinical features and response to treatment between pediatric-onset, adult-onset and elderly-onset Still’s disease.Methods Subjects included in this study were drawn from the International AutoInflammatory Disease Alliance Network registry for patients with Still’s disease.Results A total of 411 patients suffering from Still’s disease were enrolled; the disease occurred in the childhood in 65 (15.8%) patients, in the adult 314 (76.4%) patients and in the elderly in 32 (7.8%) patients. No statistically significant differences at post-hoc analysis were observed in demographic features of the disease between pediatric-onset, adult-onset and elderly-onset Still’s disease. The salmon-coloured skin rash (p=0.004), arthritis (p=0.009) and abdominal pain (p=0.007) resulted significantly more frequent among paediatric patients than in adult cases, while pleuritis (p=0.015) and arthralgia (p